Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei
Identifieur interne : 002770 ( Main/Exploration ); précédent : 002769; suivant : 002771Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei
Auteurs : Robert H. Perry ; Dorothy Irving ; Bernard E. TomlinsonSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1990.
English descriptors
- KwdEn :
Abstract
In a survey to determine the occurrence of Lewy bodies in the elderly, the prevalence rate of Lewy body formation was found to be critically dependent on the psychiatric status of control cases. In 131 controls between 51 and 100 years screened to exclude psychiatric and neurological disorders, the Lewy body prevalence rate was 2.3%, but inclusion of cases with psychiatric disorders other than Alzheimer's disease increased the prevalence rate to 9%. An age-related decline in substantia nigra and locus coeruleus neuron numbers was observed in the control group. Brain stem Lewy body formation (found in 3 cases) was not necessarily linked with neuron loss in substantia nigra, though in two of the cases significant locus coeruleus neuron loss was observed. Within the control group, there was no obvious relationship of Lewy body formation to the extent of Alzheimer-type pathology. These findings are compatible with the disease specificity of Lewy bodies and suggest that Lewy body disorders have a relatively short preclinical phase in which Lewy body formation may precede both locus coeruleus and substantia nigra neuron loss. The increase of Lewy body positive cases found when individuals with psychiatric disorders are included in the population surveyed supports the emerging concept of spectrum of a Lewy body diseases ranging from purely psychiatric disorders through combined psychoneurological or neuropsychiatric symptoms, to the classically described neurological disorders of Parkinson's disease.
Url:
DOI: 10.1016/0022-510X(90)90037-N
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei</title><author><name sortKey="Perry, Robert H" sort="Perry, Robert H" uniqKey="Perry R" first="Robert H." last="Perry">Robert H. Perry</name></author><author><name sortKey="Irving, Dorothy" sort="Irving, Dorothy" uniqKey="Irving D" first="Dorothy" last="Irving">Dorothy Irving</name></author><author><name sortKey="Tomlinson, Bernard E" sort="Tomlinson, Bernard E" uniqKey="Tomlinson B" first="Bernard E." last="Tomlinson">Bernard E. Tomlinson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2942FEBBABA4547FCCADD0E22DF90529F32E8DAC</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0022-510X(90)90037-N</idno><idno type="url">https://api.istex.fr/document/2942FEBBABA4547FCCADD0E22DF90529F32E8DAC/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001960</idno><idno type="wicri:Area/Main/Curation">001709</idno><idno type="wicri:Area/Main/Exploration">002770</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei</title><author><name sortKey="Perry, Robert H" sort="Perry, Robert H" uniqKey="Perry R" first="Robert H." last="Perry">Robert H. Perry</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE (U.K.)</wicri:noCountry></affiliation></author><author><name sortKey="Irving, Dorothy" sort="Irving, Dorothy" uniqKey="Irving D" first="Dorothy" last="Irving">Dorothy Irving</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE (U.K.)</wicri:noCountry></affiliation></author><author><name sortKey="Tomlinson, Bernard E" sort="Tomlinson, Bernard E" uniqKey="Tomlinson B" first="Bernard E." last="Tomlinson">Bernard E. Tomlinson</name><affiliation><wicri:noCountry code="subField">Newcastle upon Tyne NE4 6BE (U.K.)</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">100</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">2942FEBBABA4547FCCADD0E22DF90529F32E8DAC</idno><idno type="DOI">10.1016/0022-510X(90)90037-N</idno><idno type="PII">0022-510X(90)90037-N</idno><idno type="ArticleID">9090037N</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging</term><term>Alzheimer-type pathology</term><term>Catecholamine</term><term>Controls</term><term>Lewy bodies</term><term>Lewy body disease</term><term>Locus coeruleus</term><term>Nuclei</term><term>Senile dementia Lewy body type</term><term>Substantia nigra</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a survey to determine the occurrence of Lewy bodies in the elderly, the prevalence rate of Lewy body formation was found to be critically dependent on the psychiatric status of control cases. In 131 controls between 51 and 100 years screened to exclude psychiatric and neurological disorders, the Lewy body prevalence rate was 2.3%, but inclusion of cases with psychiatric disorders other than Alzheimer's disease increased the prevalence rate to 9%. An age-related decline in substantia nigra and locus coeruleus neuron numbers was observed in the control group. Brain stem Lewy body formation (found in 3 cases) was not necessarily linked with neuron loss in substantia nigra, though in two of the cases significant locus coeruleus neuron loss was observed. Within the control group, there was no obvious relationship of Lewy body formation to the extent of Alzheimer-type pathology. These findings are compatible with the disease specificity of Lewy bodies and suggest that Lewy body disorders have a relatively short preclinical phase in which Lewy body formation may precede both locus coeruleus and substantia nigra neuron loss. The increase of Lewy body positive cases found when individuals with psychiatric disorders are included in the population surveyed supports the emerging concept of spectrum of a Lewy body diseases ranging from purely psychiatric disorders through combined psychoneurological or neuropsychiatric symptoms, to the classically described neurological disorders of Parkinson's disease.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Irving, Dorothy" sort="Irving, Dorothy" uniqKey="Irving D" first="Dorothy" last="Irving">Dorothy Irving</name><name sortKey="Perry, Robert H" sort="Perry, Robert H" uniqKey="Perry R" first="Robert H." last="Perry">Robert H. Perry</name><name sortKey="Tomlinson, Bernard E" sort="Tomlinson, Bernard E" uniqKey="Tomlinson B" first="Bernard E." last="Tomlinson">Bernard E. Tomlinson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002770 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002770 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2942FEBBABA4547FCCADD0E22DF90529F32E8DAC
|texte= Lewy body prevalence in the aging brain: relationship to neuropsychiatric disorders, Alzheimer-type pathology and catecholaminergic nuclei
}}
| This area was generated with Dilib version V0.6.23. |  |